Argyrophilic grain disease (AGD) was first described as a degenerative disease characterized by argyrophilic grains (AGs) in the entorhinal cortex, hippocampus, amygdala and neighbouring temporal cortex in a subset of patients who had suffered from adult onset dementia (Braak and Braak, 1987, 1989).Although the seminal descriptions emphasized the lack of Alzheimer changes, subsequent studies have show…

Moreover, a common genetic background regarding the tau gene haplotype has been suggested for AgD, PSP and CBD. Copyright © 2013 New disease, which is not fully characterised. AgD shows a significant correlation with advancing age, and it became apparent from recent clinicopathological studies that it might account for approximately 5% of all dementia cases. Argyrophilic grain disease：neuropathology, frequency in a dementia brain bank and lack of relationship with apolipoprotein E. Brain Pathol. Dementia with Lewy bodies from the perspective of tauopathy. The diagnosis is almost entirely made by post-mortem examination. New disease, which is not fully characterised. Grains are composed of abnormally phosphorylated tau protein with 4 repeats. • Primary age-related tauopathy (PART)/Neurofibrillary tangle-predominant senile dementia, with NFTs similar to AD, but without plaques. Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians. Dementia with grains, also referred to as argyrophilic grain disease, is a morphological condition in elderly individuals histologically characterised by the widespread occurrence of minute, spindle or comma-shaped argyrophilic, tau-immunoreactive structures distinct from neuropil threads that are p ….

Lack of relationship with apolipoprotein E4.1 to 5% of AD patients (Togo T. et al, 2002).It is almost impossible to distinguish from late-onset Alzheimer’s disease. 8）Iseki E, Togo T, Suzuki K, et al. However, although there are currently only limited data available, AgD seems to be clinically distinct from PSP and CBD and shares rather features of (mild) AD or other forms of 'limbic' dementias, among them senile dementia with tangles and the localized form of AD. Clinically it is hard to distinguish from late-onset AD.The Neuron degeneration likely associated with dysfunction of tau protein.

Further immunohistochemical and biochemical studies revealed that AgD is a four-repeat (4R) tauopathy similar to PSP and corticobasal degeneration (CBD), but distinct from Alzheimer's disease (AD) and Pick's disease. The initial reports of argyrophilic grain disease pathology from autopsy series demonstrated an increased frequency with advanced age as well as dementia.49 The prevalence of argyrophilic grain disease pathology in cases of dementia with advanced age can be as high as 42%.4 Argyrophilic grain disease has also been reported to affect 30% of centenarians lacking the signs and symptoms of overt dementia.49,58 The clinical features of argyrophilic grain disease … Argyrophilic grain disease (AgD) is a late-onset dementia morphologically characterized by the presence of abundant spindle-shaped argyrophilic grains (ArG) in neuronal processes and coiled bodies in oligodendrocytes. Acta Neuropathol. Here we report autopsy findings from an 87-year-old Japanese male SCA31 patient with dementia. 2002；12（1）：45︲52. A sporadic late-onset form of dementia characterised by a neuro-degenerative process, which mainly affects limbic structures (amygdala, hippocampus and mediobasal temporal/entorhinal cortex).It is named after silver-staining (argyrophilic) grains or coiled bodies within the cytoplasm of neurons that consist mainly of tau protein isoforms with four microtubule-binding repeates (4-R tau).Braak's diseaseReduction of short-term memory, disorders of word finding, disorders of reading and writing, disorientation, behavioural disturbances (personality changes, emotional disorders with aggression and ill-temper) may precede or follow memory failure. A sporadic late-onset form of dementia characterised by a neuro-degenerative process, which mainly affects limbic structures (amygdala, hippocampus and mediobasal temporal/entorhinal cortex).It is named after silver-staining (argyrophilic) grains or coiled bodies within the cytoplasm of neurons that consist mainly of tau protein isoforms with four microtubule-binding repeates (4-R tau). Neuropathological examination showed findings compatible with SCA31 in the cerebellum accompanied by the finding of argyrophilic grains.